Searchable abstracts of presentations at key conferences in endocrinology

ea0050p006 | Adrenal and Steroids | SFEBES2017

Improving the therapeutic index of topical anti-inflammatory steroids: angiostatic effects of 5α-tetrahydrocorticosterone vs hydrocortisone

Abernethie Amber J , Maltese Giorgia , Livingstone Dawn EW , Gastaldello Annalisa , Morgan Ruth A , Walker Brian R , Hadoke Patrick WF , Andrew Ruth

Glucocorticoids (GC) have potent anti-inflammatory effects, acting mainly through the glucocorticoid receptor (GR). However GCs have debilitating side effects and a safer alternative is required. 5α-tetrahydrocorticosterone (5αTHB, a metabolite of the natural rodent glucocorticoid corticosterone) may provide a solution: 5αTHB is anti-inflammatory in vivo, effective topically to suppress irritant dermatitis, but with fewer syst...

ea0050p006 | Adrenal and Steroids | SFEBES2017

Improving the therapeutic index of topical anti-inflammatory steroids: angiostatic effects of 5α-tetrahydrocorticosterone vs hydrocortisone

Abernethie Amber J , Maltese Giorgia , Livingstone Dawn EW , Gastaldello Annalisa , Morgan Ruth A , Walker Brian R , Hadoke Patrick WF , Andrew Ruth

Glucocorticoids (GC) have potent anti-inflammatory effects, acting mainly through the glucocorticoid receptor (GR). However GCs have debilitating side effects and a safer alternative is required. 5α-tetrahydrocorticosterone (5αTHB, a metabolite of the natural rodent glucocorticoid corticosterone) may provide a solution: 5αTHB is anti-inflammatory in vivo, effective topically to suppress irritant dermatitis, but with fewer syst...